Prostate Cancer

Short Term ADT with Radiotherapy As Salvage Treatment After Surgery: Update at 9 years of the GETUG-AFU 16 phase III Randomized Trial 

Findings confirm the better strategy for salvage therapy after failed surgery for prostate cancer is ADT along with radiotherapy,

Reporting on Apalutamide (Erleada) for Castrate Sensitive Prostate Cancer

The use of apalutamide (Erleada) improved radiographic progression-free survival with a 52% reduction in risk of death or radiographic progression; that benefit was observed across all subgroups analyzed in the TITAN TRIAL for men with progressing prostate cancer that is still hormone sensitive. The median radiographic progression-free survival was not reached in the apalutamide group and was 22.1 months in the placebo group.

Lynparza with Zytiga Improves Outcomes

Recently presented data has shown that there is a clinical improvement in median radiologic progression-free survival (rPFS) when olaparib (Lynparza) is used in combination with abiraterone (ZYTIGA) compared to abiraterone alone in men with metastatic castration-resistant prostate cancer (mCRPC). 

Does Hormone Therapy (ADT) Work?

Through the work of Huggins et al. [1] in 1941, it was shown that metastatic prostate cancer responds positively to an orchiectomy (surgical castration). We now know that there isn’t any other therapy which produces a more reliable regression of both distant and local disease than androgen withdrawal (ADT). 

What is the Correct Treatment Protocol if you Develop Lymph Node Metastasis after Surgery?

Having positive lymph node metastasis (LNM or pN1) after a radical prostatectomy (RP) to treat prostate cancer is a poor prognostic indicator.  Knowing what the next best course of treatment is if you are in this situation remains questionable.  To begin to understand and better answer this problem a group of researchers performed a comparative analysis of three of the current management strategies for men with positive lymph nodes after RP.

Is Salvage Surgery Effective After Failed Radiation Therapy?

If you have a recurrence of your prostate cancer after primary radiation therapy can a salvage radical prostatectomy (SRP) provide you with any benefits?