Provenge

A Dive Into the Data Showing African American Men Do Better Than Caucasian Men with Provenge And All Men Live Longer If They Receive Provenge When Their PSA Scores Are Low

 African American men face many different health disparities with most of the disparities being weighed against them.  There is one notable exception, African American (AA) men have a huge, significant overall survival benefit when given Sipuleucel-T (Provenge) equal to 9.5 months over their Caucasian counterparts!

Provenge When Used In Castrate Sensitive Men with Prostate Cancer Changes PSA Kinetics, But Does Not Effect Time To Bio-Chemical Failure 

The understanding that the earlier Provenge is used in castrate resistant men with prostate cancer has led many men to ask why not use Provenge even earlier when they are still castrate sensitive?  This question is an excellent one which follows the logical next step; however, the answer is surprising! 

Black Men with Prostate Cancer Are More Responsive to Radiation Than White Men

Recently released and unexpected findings have been announced, contrary to previous understandings, black men who received primary radiation therapy to treat their prostate cancer had lower rates of biochemical cancer recurrence than white men.  They also had a lower rate of developing distant metastasis.  

Provenge and Clinical Outcomes by Baseline PSA Level

Provenge (Sipuleucel-T) is the first FDA approved cancer vaccine and it is still the only immune therapy approved for Prostate Cancer. In a post-hoc analysis it was demonstrated that those men who have lower PSA scores had a superior overall survival. The analysis also showed that men who had Provenge treatment have a lower risk of cardiovascular events.