TRITON2

Understanding the PARP Inhibitors - Who Will Benefit?

Understanding the PARP Inhibitors - Who Will Benefit?

LYNPARZA (olaparib) and RUBRACA (rucaparib) are PARP Inhibitors that were FDA approved in May of 2020 for men with castrate resistant prostate cancer who also have certain genetic mutations. The FDA also approved certain Companion Diagnostic genetic tests to go along with the decision making to use these PARP Inhibitors.

There is a lot of information now available with these recent developments which makes decision making confusing.

What are the Important DNA Repair Mutations in Prostate Cancer?

There has been much discussion as well as clinical trials about the use of personal genetic information, specifically the presence of mutations in the DNA repair genes such as BRACA2, with the successful use of PARP-Inhibitors and in confirming our understanding that the occurrences of these genetic mutations are an indication of a poor prognosis.  

BRACA is not the only DNA repair pathway you nee to be aware of if you have Prostate Cancer. Learn about to other mutations you need to known.