HERO demonstrated that Orgovyx was superior to Lupron in maintaining castration from day 29 up to week 48. Orgovyx also showed an almost a five-fold reduction in the risk of subsequent major cardiac events, a concern for men on Lupron.
Hope - Maybe Changing Hormone Therapy?
Does Hormone Therapy (ADT) Work?
Through the work of Huggins et al. [1] in 1941, it was shown that metastatic prostate cancer responds positively to an orchiectomy (surgical castration). We now know that there isn’t any other therapy which produces a more reliable regression of both distant and local disease than androgen withdrawal (ADT).
Is Abiraterone Acetate (Zytiga) A Good Alternative for Men with Prostate Cancer Who Are Not Responsive to Androgen Deprivation Therapy (ADT)?
The Difference Between an Agonist, an Antiandrogen and an Antagonist in ADT?
Questioning the Wisdom of Combined Androgen Therapy
One of the questions that often come up is how long a man should use an antiandrogen drug like Casodex along with a GnRH agonist like Lupron or Zoladex? There is no question that an antiandrogen needs to be used before the first dosage of the agonist (Lupron), but should the antiandrogen be stopped or should it be continued along with the agonist (combining an antiandrogen along with the GnRH agonist is often referred to as a combined androgen blockade)?
The Difference Between Agonists, Antiandrogens, and Antagonist in ADT
Firmagon Is Superior To The LHRH Agonists Like Lupron
Hormone Therapy Negatively Impacts African American Men
A study found that African American men had a higher rate of death from non-prostate cancer problems than non-African American men after receiving short-term hormone therapy (ADT) prior to having brachytherapy (seeds). There are significant implications beyond this research for African Americans using ADT for any purpose, including he treatment of advanced (progressive) prostate cancer.
